abstract：:Early admission to the neurosciences intensive care unit (NSICU) is associated with improved patient outcomes. Natural language processing offers new possibilities for mining free text in electronic health record data. We sought to develop a machine learning model using both tabular and free text data to identify pati...

journal_title：Scientific reports

authors： Klang E,Kummer BR,Dangayach NS,Zhong A,Kia MA,Timsina P,Cossentino I,Costa AB,Levin MA,Oermann EK

更新日期：2021-01-14 00:00:00

abstract：:The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using gas chromatography ...

journal_title：Scientific reports

authors： Khor BH,Sahathevan S,Sualeheen A,Ali MSM,Narayanan SS,Chinna K,Gafor AHA,Goh BL,Ahmad G,Morad Z,Daud ZAM,Khosla P,Sundram K,Karupaiah T,PaTCH Investigators.

更新日期：2021-01-14 00:00:00

abstract：:As an analytic pipeline for quantitative imaging feature extraction and analysis, radiomics has grown rapidly in the past decade. On the other hand, recent advances in deep learning and transfer learning have shown significant potential in the quantitative medical imaging field, raising the research question of whethe...

journal_title：Scientific reports

authors： Zhang Y,Lobo-Mueller EM,Karanicolas P,Gallinger S,Haider MA,Khalvati F

更新日期：2021-01-14 00:00:00

abstract：:This study investigated the efficacy of a biphasic synthetic β-tricalcium phosphate/calcium sulfate (β-TCP/CS) bone graft substitute for compatibility with vancomycin (V) in combination with tobramycin (T) or gentamicin (G) evidenced by the duration of potency and the prevention and killing efficacies of P. aeruginosa...

journal_title：Scientific reports

authors： Jiang N,Dusane DH,Brooks JR,Delury CP,Aiken SS,Laycock PA,Stoodley P

更新日期：2021-01-14 00:00:00

abstract：:Toll-like receptor 9 (TLR9) is crucial to the host immune response against fungi, such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, but its importance in Cryptococcus gattii infection is unknown. Our study aimed to understand the role of TLR9 during the course of experimental C. gattii infec...

journal_title：Scientific reports

authors： da Silva-Junior EB,Firmino-Cruz L,Guimarães-de-Oliveira JC,De-Medeiros JVR,de Oliveira Nascimento D,Freire-de-Lima M,de Brito-Gitirana L,Morrot A,Previato JO,Mendonça-Previato L,Decote-Ricardo D,de Matos Guedes HL,Freire-de-Lima

更新日期：2021-01-14 00:00:00

abstract：:Methamphetamine (METH) is a highly addictive psychostimulant that causes long-lasting effects in the brain and increases the risk of developing neurodegenerative diseases. The cellular and molecular effects of METH in the brain are functionally linked to alterations in glutamate levels. Despite the well-documented eff...

journal_title：Scientific reports

authors： Jones B,Balasubramaniam M,Lebowitz JJ,Taylor A,Villalta F,Khoshbouei H,Grueter C,Grueter B,Dash C,Pandhare J

更新日期：2021-01-14 00:00:00

abstract：:In bacteria, the SecA ATPase provides the driving force for protein secretion via the SecYEG translocon. While the dynamic interplay between SecA and SecYEG in translocation is widely appreciated, it is not clear how SecA associates with the translocon in the crowded cellular environment. We use super-resolution micro...

journal_title：Scientific reports

authors： Seinen AB,Spakman D,van Oijen AM,Driessen AJM

更新日期：2021-01-14 00:00:00

abstract：:The kidney is a high-energy demand organ rich in mitochondria especially renal tubular cells. Emerging evidence suggests that mitochondrial dysfunction, redox imbalance and kidney injury are interconnected. Artemether has biological effects by targeting mitochondria and exhibits potential therapeutic value for kidney ...

journal_title：Scientific reports

authors： Han P,Cai Y,Wang Y,Weng W,Chen Y,Wang M,Zhan H,Yu X,Wang T,Shao M,Sun H

更新日期：2021-01-14 00:00:00

abstract：:Selective amygdalohippocampectomy is an effective treatment for patients with therapy-refractory temporal lobe epilepsy but may cause visual field defect (VFD). Here, we aimed to describe tissue-specific pre- and postoperative imaging correlates of the VFD severity using whole-brain analyses from voxel- to network-lev...

journal_title：Scientific reports

authors： David B,Eberle J,Delev D,Gaubatz J,Prillwitz CC,Wagner J,Schoene-Bake JC,Luechters G,Radbruch A,Wabbels B,Schramm J,Weber B,Surges R,Elger CE,Rüber T

更新日期：2021-01-14 00:00:00

abstract：:The ecosystem of the Source Region of Yangtze River (SRYR) is highly susceptible to climate change. In this study, the spatial-temporal variation of NPP from 2000 to 2014 was analyzed, using outputs of Carnegie-Ames-Stanford Approach model. Then the correlation characteristics of NPP and climatic factors were evaluate...

journal_title：Scientific reports

authors： Yuan Z,Wang Y,Xu J,Wu Z

更新日期：2021-01-14 00:00:00

abstract：:There is significant interest in understanding the pathophysiology of Obsessive-Compulsive Disorder (OCD) using resting-state fMRI (rsfMRI). Previous studies acknowledge abnormalities within and beyond the fronto-striato-limbic circuit in OCD that require further clarifications. However, limited information could be i...

journal_title：Scientific reports

authors： Kashyap R,Eng GK,Bhattacharjee S,Gupta B,Ho R,Ho CSH,Zhang M,Mahendran R,Sim K,Chen SHA

更新日期：2021-01-14 00:00:00

abstract：:Filamentous fungi grow exclusively at their tips, where many growth-related fungal processes, such as enzyme secretion and invasion into host cells, take place. Hyphal tips are also a site of active metabolism. Understanding metabolic dynamics within the tip region is therefore important for biotechnology and medicine...

journal_title：Scientific reports

authors： Yasuda M,Takeshita N,Shigeto S

更新日期：2021-01-14 00:00:00

abstract：:Grain boundary (GB) oxidation of proton-irradiated 304 nuclear grade stainless steel in primary water of pressurized water reactor was investigated. The investigation was conducted by studying microstructure of the oxide and oxide precursor formed at GB on an "atom-by-atom" basis by a combination of atom-probe tomogra...

journal_title：Scientific reports

authors： Deng P,Peng Q,Han EH

更新日期：2021-01-14 00:00:00

abstract：:Electroporation (EP), the increase of cell membrane permeability due to the application of electric pulses, is a universal phenomenon with a broad range of applications. In medicine, some of the foremost EP-based tumor treatments are electrochemotherapy (ECT), irreversible electroporation, and gene electrotransfer (GE...

journal_title：Scientific reports

authors： Marino M,Luján E,Mocskos E,Marshall G

更新日期：2021-01-14 00:00:00

abstract：:A highly sensitive bismuth/silver nanoparticles/Nafion-modified screen-printed graphene electrode was fabricated and was utilized for the detection of trace lead (Pb) concentrations in river water samples prior to and after remediation using calamansi (Citrofortunella Microcarpa) rinds in different forms viz., ground ...

journal_title：Scientific reports

authors： Palisoc ST,Vitto RIM,Noel MG,Palisoc KT,Natividad MT

更新日期：2021-01-14 00:00:00

abstract：:To construct a machine learning algorithm model of lymph node metastasis (LNM) in patients with poorly differentiated-type intramucosal gastric cancer. 1169 patients with postoperative gastric cancer were divided into a training group and a test group at a ratio of 7:3. The model for lymph node metastasis was establis...

journal_title：Scientific reports

authors： Zhou CM,Wang Y,Ye HT,Yan S,Ji M,Liu P,Yang JJ

更新日期：2021-01-14 00:00:00

abstract：:Alzheimer's disease (AD) is mainly characterized by the deposition of extracellular amyloid plaques and intracellular accumulation of neurofibrillary tangles (NFTs). While the recent 5xFAD AD mouse model exhibits many AD-related phenotypes and a relatively early and aggressive amyloid β production, it does not show NF...

journal_title：Scientific reports

authors： Kang S,Kim J,Chang KA

更新日期：2021-01-14 00:00:00

abstract：:The traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated "mcDESPOT", uses a more efficient steady-state acquisition to generate an eq...

journal_title：Scientific reports

authors： Dvorak AV,Ljungberg E,Vavasour IM,Lee LE,Abel S,Li DKB,Traboulsee A,MacKay AL,Kolind SH

更新日期：2021-01-14 00:00:00

abstract：:Embryonic stem cells (ESCs) and epiblast-like cells (EpiLCs) recapitulate in vitro the epiblast first cell lineage decision, allowing characterization of the molecular mechanisms underlying pluripotent state transition. Here, we performed a comprehensive and comparative analysis of total glycomes of mouse ESCs and Epi...

journal_title：Scientific reports

authors： Pecori F,Yokota I,Hanamatsu H,Miura T,Ogura C,Ota H,Furukawa JI,Oki S,Yamamoto K,Yoshie O,Nishihara S

更新日期：2021-01-14 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive brain primary malignancy. Toll-like receptor 4 (TLR4) has a dual role in cell fate, promoting cell survival or death depending on the context. Here, we analyzed TLR4 expression in different grades of astrocytoma, and observed increased expression in tumors, mainly in GBM, comp...

journal_title：Scientific reports

authors： Moretti IF,Lerario AM,Trombetta-Lima M,Sola PR,da Silva Soares R,Oba-Shinjo SM,Marie SKN

更新日期：2021-01-14 00:00:00

abstract：:Stemborers (Busseola fusca, Sesamia calamistis and Chilo partellus), the fall armyworm (Spodoptera frugiperda) and associated parasitoids constitute an interacting system in maize fields in Kenya. This work aims at developing and evaluating models that represent the evolution of those interactions by applying system t...

journal_title：Scientific reports

authors： Sokame BM,Tonnang HEZ,Subramanian S,Bruce AY,Dubois T,Ekesi S,Calatayud PA

更新日期：2021-01-14 00:00:00

abstract：:TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products. Here, this is demonstrated through the use of classically-activated and alternatively-activated macrophages. We show that, when polarized, ...

journal_title：Scientific reports

authors： Stephens M,Liao S,von der Weid PY

更新日期：2021-01-14 00:00:00

abstract：:Connectivity is fundamentally important for shaping the resilience of complex human and natural networks when systems are disturbed. Ecosystem resilience is, in part, shaped by the spatial arrangement of habitats, the permeability and fluxes between them, the stabilising functions performed by organisms, their dispers...

journal_title：Scientific reports

authors： Pearson RM,Schlacher TA,Jinks KI,Olds AD,Brown CJ,Connolly RM

更新日期：2021-01-13 00:00:00

abstract：:The aim of the study was to compare background characteristics, microbiology and outcome of patients with right-sided and left-sided intravenous drug use (IDU) associated infective endocarditis (IE). A nationwide retrospective study using the Swedish Registry on Infective Endocarditis between 2008 and 2019 was conduct...

journal_title：Scientific reports

authors： Clarelin A,Rasmussen M,Olaison L,Ragnarsson S

更新日期：2021-01-13 00:00:00

abstract：:To assess extraspinal findings (ESFs) prevalence in lumbar spine MRI, including clinically significant findings using a systematic approach, and to determine their reporting rate. Lumbar spine MRI scans were retrospectively reviewed over 18 months by two radiologists. Reading discrepancies were resolved by consensus. ...

journal_title：Scientific reports

authors： Khasawneh RA,Mohaidat Z,Khasawneh FA,Farah A,Gharaibeh M,El-Heis M

更新日期：2021-01-13 00:00:00

abstract：:The spreading of cooperation in structured population is a challenging problem which can be observed at different scales of social and biological organization. Generally, the problem is studied by evaluating the chances that few initial invading cooperators, randomly appearing in a network, can lead to the spreading o...

journal_title：Scientific reports

authors： Yang G,Cavaliere M,Zhu C,Perc M

更新日期：2021-01-13 00:00:00

abstract：:Airports can affect birds by hindering acoustic communication. Here, we investigated the impacts of aircraft events on vocal behavior in wood thrush (Hylocichla mustelina) breeding one mile from an airport in Ithaca, NY, USA. We identified the number of wood thrush songs between 0500 and 0800 h at various distances fr...

journal_title：Scientific reports

authors： Injaian AS,Lane ED,Klinck H

更新日期：2021-01-13 00:00:00

abstract：:Neovascularization of the erectile tissue emerges as a beneficial curative approach to treat erectile dysfunction (ED). Here we for the first time report the unexpected role of vasohibin-1 (VASH1), mainly known as an anti-angiogenic factor, in restoring erectile function in diabetic mice. A diabetic patient has lower ...

journal_title：Scientific reports

authors： Song KM,Kim WJ,Choi MJ,Kwon KD,Limanjaya A,Ghatak K,Ock J,Yin GN,Sato Y,Hong SS,Ryu JK,Suh JK

更新日期：2021-01-13 00:00:00

abstract：:To determine factors associated with delayed discharge of hospitalized patients with coronavirus disease (COVID-19). This retrospective cohort study included 47 patients with COVID-19 admitted to three hospitals in Quanzhou City, Fujian Province, China, between January 21, 2020 and March 6, 2020. Univariate and multiv...

journal_title：Scientific reports

authors： Lin P,Chen W,Huang H,Lin Y,Cai M,Lin D,Cai H,Su Z,Zhuang X,Yu X

更新日期：2021-01-13 00:00:00

abstract：:Recently, there has been a debate whether implicit Theory of Mind can be reliably measured using anticipatory looking tasks. Previous anticipatory looking paradigms used video stimuli to measure implicit Theory of Mind; however, numerous replications of these paradigms were unsuccessful. This lack of replications may ...

journal_title：Scientific reports

authors： Kulke L,Hinrichs MAB

更新日期：2021-01-13 00:00:00

abstract：:Design and development of efficient processes for continuous manufacturing of solid dosage oral formulations is of crucial importance for pharmaceutical industry in order to implement the Quality-by-Design paradigm. Supercritical solvent-based manufacturing can be utilized in pharmaceutical processing owing to its inh...

journal_title：Scientific reports

authors： Pishnamazi M,Zabihi S,Jamshidian S,Borousan F,Hezave AZ,Marjani A,Shirazian S

更新日期：2021-01-13 00:00:00

abstract：:Roselle-Hibiscus sabdariffa L. leaves at different stages of growth, calyces and seeds were analyzed for nutritional and anti-nutritional factors. All the treatments contained a good but varied proportion of carbohydrate in a range of 26.93-54.13%, crude protein from 5.7 to 27.06%, crude fat 1.16-13.09%, crude fibre 1...

journal_title：Scientific reports

authors： Salami SO,Afolayan AJ

更新日期：2021-01-13 00:00:00

abstract：:We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populat...

journal_title：Scientific reports

authors： Debortoli G,de Araujo GS,Fortes-Lima C,Parra EJ,Suarez-Kurtz G

更新日期：2021-01-13 00:00:00

abstract：:The green bacterial biosynthesis of lead sulfide nanocrystallites by L-cysteine-desulfurizing bacterium Lysinibacillus sphaericus SH72 was demonstrated in this work. Nanocrystals formed by this bacterial method were characterized using the mineralogical and morphological approaches. The results revealed that the micro...

journal_title：Scientific reports

authors： Wei S,Guo C,Wang L,Xu J,Dong H

更新日期：2021-01-13 00:00:00

abstract：:Circulating tumor DNA (ctDNA) has become an attractive biomarker in human oncology, and its use may be informative in canine cancer. Thus, we used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the pla...

journal_title：Scientific reports

authors： Prouteau A,Denis JA,De Fornel P,Cadieu E,Derrien T,Kergal C,Botherel N,Ulvé R,Rault M,Bouzidi A,François R,Dorso L,Lespagnol A,Devauchelle P,Abadie J,André C,Hédan B

更新日期：2021-01-13 00:00:00

abstract：:Survival analyses for malignancies, including renal cell carcinoma (RCC), have primarily been conducted using the Cox proportional hazards (CPH) model. We compared the random survival forest (RSF) and DeepSurv models with the CPH model to predict recurrence-free survival (RFS) and cancer-specific survival (CSS) in non...

journal_title：Scientific reports

authors： Byun SS,Heo TS,Choi JM,Jeong YS,Kim YS,Lee WK,Kim C

更新日期：2021-01-13 00:00:00

abstract：:Human papillomavirus (HPV) is the leading cause of cervical cancer and has been implicated in several other cancer types including vaginal, vulvar, penile, and oropharyngeal cancers. Despite the recent availability of a vaccine, there are still over 310,000 deaths each year worldwide. Current treatments for HPV-mediat...

journal_title：Scientific reports

authors： Padash Barmchi M,Thomas M,Thatte JV,Vats A,Zhang B,Cagan RL,Banks L

更新日期：2021-01-13 00:00:00

abstract：:The current assessment of corneal vascularisation (CV) relies on slit-lamp examination, which may be subjective. Dye-based angiographies, like indocyanine green angiography (ICGA), allows for good visualisation of anterior segment blood vessels. However, ICGA is invasive and can be associated with systemic adverse eff...

journal_title：Scientific reports

authors： Ong HS,Tey KY,Ke M,Tan B,Chua J,Schmetterer L,Mehta JS,Ang M

更新日期：2021-01-13 00:00:00

abstract：:Based on a hybrid pumping method consisting of a 1150 nm continuous-wave pump source and a 1950 nm pulsed pump source, we demonstrate a power controllable gain-switched fiber laser in dual wavebands at ~ 3 μm and ~ 2.1 μm. Different pumping schemes for pumping a Ho3+-doped ZBLAN fiber are studied. Using only the 1950 ...

journal_title：Scientific reports

authors： Shi Y,Li J,Lai C,Peng H,Zhu C,Liu Y

更新日期：2021-01-13 00:00:00

abstract：:Protein phosphorylation enables a rapid adjustment of cellular activities to diverse intracellular and environmental stimuli. Many phosphoproteins are targeted on more than one site, which allows the integration of multiple signals and the implementation of complex responses. However, the hierarchy and interplay betwe...

journal_title：Scientific reports

authors： Dengler L,Örd M,Schwab LM,Loog M,Ewald JC

更新日期：2021-01-13 00:00:00